Our laboratory studies the events that occur early during the virus-host interaction and that determine the successful transition from the less specific initial innate immune response to the more specific adaptive immune response. We are particularly interested in the immune responses to viruses that are well-adapted to the host and that have developed efficient mechanisms to antagonize the immune system. We use a number of mouse models of respiratory infection including influenza virus, respiratory syncytial virus, human metapneumovirus, and the mouse pathogen Sendai virus. We have strong virology and immunology components and use multiple techniques in vitro and in vivo to gather an inclusive mechanistic understanding of the processes that determine the successful development of antiviral immunity. Our work extends to the study of strategies for the improvement of vaccines and to the analysis of determinants of virus persistence.