The understanding of the processes that lead to the efficient generation of an immune response is critical for the development of therapies and vaccines against threatening pathogens. Our lab studies the events that occur early during the virus-host interaction and that determine the successful transition from the less specific initial innate immune response to the more specific adaptive immune response. We work with a number of mouse models of respiratory infection including influenza virus, respiratory syncytial virus, human metapneumovirus, and the mouse pathogen Sendai virus. We have strong virology and immunology components and use multiple techniques in vitro and in vivo to gather an inclusive mechanistic understanding of the processes that determine the successful development of anti-viral immunity. Our work extends to the study of strategies for the improvement of vaccines and to the analysis of determinants of virus persistence.
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Contact information:
Carolina B. López Ph.D.
Assistant Professor
Department of Pathobiology
School of Veterinary Medicine
University of Pennsylvania
380 S University Avenue Philadelphia,
PA 19104-4539
Office: Hill Pavilion 318
Phone: 1-215-573-3493
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