CURRENT MEMBERS

Yan Sun, PhD

Research Associate since March, 2018

Previously Postdoctoral Researcher (2013-2018)

Ph.D. in Pathobiology from the University of Illinois Urbana-Champaign

yansun@vet.upenn.edu

Publications

1. Mercado-López M, Cotter CR, Kim WK, Muñoz L, Sun Y, Tapia K, and López CB. (2013) Highly Immunostimulatory RNA Derived from a Sendai Virus Defective Viral Genome. Vaccine. 2013 Oct 4. pii: S0264-410X(13)01294-2. doi: 10.1016/j.vaccine.2013.09.040. [Epub ahead of print] PMID: 2409987. PubMed link.2. Tapia K, Kim WK, Sun Y, Mercado-López X, Dunay E, Wise M, Adu M, and López CB. (2013) Defective Viral Genomes Arising In Vivo Provide Critical Danger Signals for the Triggering of Lung Antiviral Immunity. PLOS Pathogens 9(10): e1003703. doi:10.1371/journal.ppat.1003703. * Featured Article. *Co-first authors. PubMed link3. Sun Y, Jain D, Koziol-White CJ, Genoyer E, Gilbert M, Tapia K, Panettieri RA, Hodinka RL, and López CB. (2015) Immunostimulatory Defective Viral Genomes Promote Strong Innate Antiviral Responses During Respiratory Syncytial Virus Infection in Mice and Humans. PLOS Pathogens. 11(9): e1005122. doi:10.1371/journal.ppat.1005122 PubMed link4. Sun Y and López CB. (2016) Preparation of respiratory syncytial virus stocks and purification of defective viral particles. Bio-protocol 6(10): e1820. http://www.bio-protocol.org/e1820. 5. Sun Y and López CB. (2016) Respiratory syncytial virus infection in mice and detection of viral genomes in the lung using RT-qPCR. Bio-protocol 6(10): e1819. http://www.bio-protocol.org/e1819.6. Sun Y and López CB. (2016) The innate immune response to RSV: Advances in our understanding of critical viral and host factors (Review). Vaccine http://dx.doi.org/10.1016/j.vaccine.2016.09.030 7. Muallem G, Wagage S, Sun Y, DeLong JH, Valenzuela A, Harms Pritchard G, Christian, DA, Fang, Q, Buza E, Jain D, Elloso MM, López CB#, and Hunter CA#. (2017) IL-27 Limits Type 2 Immunopathology Following Parainfluenza Virus Infection. PLOS Pathogens 13(1):e1006173. doi: 10.1371/journal.ppat.1006173. #Senior authors. Publication link.8. Kenny A, Dowdle JA, Bozzacco L, McMichael TM, St. Gelais C, Panfil AR, Sun Y, Anderson MZ, Green PL, López CB, Rosenberg BR, Wu L, and Yount JS. Human Genetic Determinants of Viral Diseases (2017) (Review), Annual Reviews of Genetics. doi/abs/10.1146/annurev-genet-120116-023425. Publication link9. Xu J,* Sun Y*, Li Y, Ruthel G, Weiss SR, Raj, A, Beiting D and López CB. (2017) Replication Defective Viral Genomes Exploit A Cellular Pro-Survival Mechanism To Establish Paramyxovirus Persistence. [Preprint: BioRxiv, doi: https://doi.org/10.1101/120766]. Nature Communications Oct 6;8(1):799. doi: 10.1038/s41467-017-00909-6. Publication link.10. Sun Y, Kim EJ, Felt SA, Taylor LJ, Agarwal D, Grant GR, and López CB. (2019) ­­­­­­­­­A specific sequence in the genome of respiratory syncytial virus regulates the generation of copy-back defective viral genomes [Preprint: https://www.biorxiv.org/content/early/2018/06/16/349001]. PloS Pathogens, 15(4): e1007707. https://doi.org/10.1371/journal.ppat.1007707.

Emmanuelle Genoyer

Graduate Student, joined the lab in June of 2015

MVP Program, Cell & Molecular Biology Graduate Group

egenoyer@pennmedicine.upenn.edu

Publications:

1. Sun Y, Jain D, Koziol-White CJ, Genoyer E, Gilbert M, Tapia K, Panettieri RA, Hodinka RL, and López CB. (2015) Immunostimulatory Defective Viral Genomes Promote Strong Innate Antiviral Responses During Respiratory Syncytial Virus Infection in Mice and Humans. PLOS Pathogens. 11(9): e1005122. doi:10.1371/journal.ppat.1005122 PubMed link2. Genoyer E and López CB (2019) Distinct intracellular distribution of full-length and defective viral RNA genomes drives functional heterogeneity during infection. J. Virol. DOI: 10.1128/JVI.01579-18. Publication link3. Genoyer E and López CB. (2019) ­­­­­­­­­(Review) The Impact of Defective Viruses on Infection and Immunity. Annu Rev Virol. doi: 10.1146/annurev-virology-092818-015652

Devin Fisher

Graduate Student, joined the lab in June of 2016

MVP Program, Cell & Molecular Biology Graduate Group

fdevin@pennmedicine.upenn.edu

Publications:

1. Fisher DG, Coppock GM, and López CB (2018) Virus-derived immunostimulatory RNA induces type I IFN-dependent antibodies and T-cell responses during vaccination. Vaccine, 36(28):4039-4045. doi: 10.1016/j.vaccine.2018.05.100. Publication link.2. Sengupta S, Tang S, Devine J, Anderson S, Nayak S, Zhang C, Valenzuela A, Fisher D, Grant G, López CB, and FitzGerald G. (2019) Circadian control of lung inflammation in influenza infection. Nature Communications, doi.org/10.1038/s41467-019-11400-9.

Sebastien Felt, PhD

Postdoctoral Researcher since June, 2017

Ph.D. in Biology, Concentration in Molecular, Cellular, and Developmental Biology Sciences from the University of North Carolina at Charlotte.

sebfelt@vet.upenn.edu

Publications:

1. Sun Y, Kim EJ, Felt SA, Taylor LJ, Agarwal D, Grant GR, and López CB. (2019) ­­­­­­­­­A specific sequence in the genome of respiratory syncytial virus regulates the generation of copy-back defective viral genomes [Preprint: https://www.biorxiv.org/content/early/2018/06/16/349001]. PloS Pathogens, 15(4): e1007707. https://doi.org/10.1371/journal.ppat.1007707.

Lavinia Gonzalez

Graduate Student, joined the lab in June of 2018

MVP Program, Cell & Molecular Biology Graduate Group

golavo@pennmedicine.upenn.edu

Katherine Novak

Undergrad Researcher since September 2019

Vagelos LSM program, School of Arts and Sciences, UPenn

knovak@sas.upenn.edu

Current Rotation and Summer Students


Because we are moving soon we are not currently taking rotation or summer students