PAST MEMBERS

Post-Docs

Jie Xu, Ph.D. (2014-2017)

Went to: Project Management Scientist / Senior Fellow. Abmart Inc-China Northwestern University Joint Research Institute. Shanghai, China.

Publications:

1. Xu J, Mercado-López X, Grier J, Kim W, Chun L, Irvine EB, Del Toro Y, Kell A, Hur S, Gale M, Raj A, and López CB. (2015) Identification of a Natural Viral RNA Motif that Facilitates Viral Recognition by RIG-I-Like Receptors. mBio 6(5):e01265-15. doi:10.1128/mBio.01265-15. PubMed link2. Xu J,* Sun Y*, Li Y, Ruthel G, Weiss SR, Raj, A, Beiting D and López CB. (2017) Replication Defective Viral Genomes Exploit A Cellular Pro-Survival Mechanism To Establish Paramyxovirus Persistence. [Preprint: BioRxiv, doi: https://doi.org/10.1101/120766]. Nature Communications Oct 6;8(1):799. doi: 10.1038/s41467-017-00909-6. Publication link.

Jennifer Grier, Ph.D. (2013-2016)

Went to: Visiting Assistant Professor of Biology, Linfield College, OR.

Current position: Clinical Assistant Professor of Immunology at University of South Carolina School of Medicine Greenville, USA

Publications:

1. Xu J, Mercado-López X, Grier J, Kim W, Chun L, Irvine EB, Del Toro Y, Kell A, Hur S, Gale M, Raj A, and López CB. (2015) Identification of a Natural Viral RNA Motif that Facilitates Viral Recognition by RIG-I-Like Receptors. mBio 6(5):e01265-15. doi:10.1128/mBio.01265-15. PubMed link2. Philip NH, DeLaney A, Peterson LW, Santos-Marerro M, Grier JT, Sun Y, Wynosky-Dolfi MA, Zwack EE, Hu B, Olson TM, Rongvaux A, Pope SD, López CB, Oberst A, Beiting DP, Henao-Mejia J, and Brodsky IE. (2016) Activity of Uncleaved Caspase-8 Controls Anti-bacterial Immune Defense and TLR-Induced Cytokine Production Independent of Cell Death PLOS Pathogens 12(10): e1005910. doi:10.1371/ journal.ppat.1005910. Publication link.

Xiomara Mercado-López, Ph.D. (2010-2013)

Went to: Assistant Professor, Universidad de Puerto Rico, Campus Arecibo.

Currently: Post doctoral fellow, UPenn

Publications:

1. Mercado-López X, Cotter CR, Kim WK, Muñoz L, Sun Y, Tapia K, and López CB. (2013) Highly Immunostimulatory RNA Derived from a Sendai Virus Defective Viral Genome. Vaccine. 2013 Oct 4. pii: S0264-410X(13)01294-2. doi: 10.1016/j.vaccine.2013.09.040. [Epub ahead of print] PMID: 2409987. PubMed link.2. Tapia K, Kim WK, Sun Y, Mercado-López X, Dunay E, Wise M, Adu M, and López CB. (2013) Defective Viral Genomes Arising In Vivo Provide Critical Danger Signals for the Triggering of Lung Antiviral Immunity. PLOS Pathogens 9(10): e1003703. doi:10.1371/journal.ppat.1003703. * Featured Article. *Co-first authors. PubMed link3. Xu J, Mercado-López X, Grier J, Kim W, Chun L, Irvine EB, Del Toro Y, Kell A, Hur S, Gale M, Raj A, and López CB. (2015) Identification of a Natural Viral RNA Motif that Facilitates Viral Recognition by RIG-I-Like Receptors. mBio 6(5):e01265-15. doi:10.1128/mBio.01265-15. PubMed link

Maria Ines Barria, PhD (2009-2010)

Went to: Postdoctoral Fellow, Mount Sinai School of Medicine, NY

Current position: Assistant Professor University of Concepcion, Chile.

Graduate Students

Jia Xue (2013-2015)

Position in the Lopez Lab: Visiting Scholar Graduate Student

Went to: finish her PhD in China

Publications:

1. Benitez AA, Panis M, Xue J, Shim JV, Varble A, Frick AL, López CB, Sachs D, and tenOever BR. (2015) In vivo RNAi screening identifies MDA5 as a contributor to the cellular defense against influenza A virus. Cell Reports, published online on 11 June, 2015doi:10.1016/j.celrep.2015.05.032. PubMed link.2. Xue J, Chambers BS, Hensley SE and López CB. (2016) Propagation and characterization of influenza virus stocks that are not loaded with defective viral genomes and hemagglutinin mutations. Front. Microbiol. 7:326 doi: 10.3389/fmicb.2016.0032. PubMed link

Won-keun Kim (2008-2013)

Position in the Lopez Lab: Graduate Student, Mount Sinai School of Medicine, NY.

Went to: Research Instructor, Korea University

Current position: Assistant Professor, Department of Microbiology, Hallym University, Korea.

Publications:

1.Cotter C, Kim WK, Nguyen M, Yount J, López CB, Blaho, and Moran TM. (2011) The Virion Host Shut-off (vhs) Protein of HSV-1 Blocks the Replication-Independent Activation of NF-κB in Dendritic Cells. J. Virol. Sept 21, EPub Ahead of Print. PMID: 2193765. PubMed link.2. Mercado-López X, Cotter CR, Kim WK, Muñoz L, Sun Y, Tapia K, and López CB. (2013) Highly Immunostimulatory RNA Derived from a Sendai Virus Defective Viral Genome. Vaccine. 2013 Oct 4. pii: S0264-410X(13)01294-2. doi: 10.1016/j.vaccine.2013.09.040. [Epub ahead of print] PMID: 2409987. PubMed link.3. Tapia K, Kim WK, Sun Y, Mercado-López X, Dunay E, Wise M, Adu M, and López CB. (2013) Defective Viral Genomes Arising In Vivo Provide Critical Danger Signals for the Triggering of Lung Antiviral Immunity. PLOS Pathogens 9(10): e1003703. doi:10.1371/journal.ppat.1003703. * Featured Article. *Co-first authors. PubMed link4. Kim WK, Jain D, Sánchez MD, Koziol-White C, Matthews K, Ge M, Haczku A, Panettieri RA, Frieman MB, and López CB. (2014) Deficiency of Melanoma Differentiation-associated protein 5 results in Exacerbated Chronic Post-Viral Lung Inflammation. Am. J. Respir. Crit. Care Med. 189(4):437-48. doi: 10.1164/rccm.201307-1338OC. PMID: 24417465. PubMed link.5. Xu J, Mercado-López X, Grier J, Kim WK, Chun L, Irvine EB, Del Toro Y, Kell A, Hur S, Gale M, Raj A, and López CB. (2015) Identification of a Natural Viral RNA Motif that Facilitates Viral Recognition by RIG-I-Like Receptors. mBio 6(5):e01265-15. doi:10.1128/mBio.01265-15. PubMed link

Tamar Hermesh (2005-2010)

Position in the Lopez Lab: Graduate Student (co-mentor), Mount Sinai School of Medicine, NY.

Went to: Postdoctoral Fellow, Rockefeller University, NY

Current: Medical student, Israel.

Publications:

1. López CB, Yount JS, Hermesh T and Moran TM. (2006) Sendai Virus Infection Induces Efficient Adaptive Immunity Independently of Type I IFNs. J. Virol. 80:4538-4545. PMID: 16611914, PMCID: PMC1472017. PubMed link.2. Moltedo B, López CB, Pazos M, Becker MI, Hermesh T and Moran TM. (2009) Cutting Edge: stealth Influenza Virus Replication Precedes the Initiation of Adaptive Immunity. J. Immunol. 183:3569-3573. PMID: 19717515. PubMed link. 3. Hermesh T, Moltedo B, Moran TM and López CB. (2010) Antiviral Instruction of Bone Marrow Leukocytes during Respiratory Viral Infections. Cell Host & Microbe.7:343-353. PMID: 20478536. PMCID: PMC2874206 * Featured Article and Previewed. PubMed link.4. Hermesh T, Moltedo B, López CB and Moran TM. (2010) Buying Time—The Immune System Determinants of the Incubation Period to Respiratory Viruses-Review. Viruses 2:2541-2558. PMID: 21994630 PMCID: PMC3185581. PubMed link.5. Hermesh T, Moran TM, Jain. D, and López CB. (2012) Granulocyte colony-stimulating factor protects mice during respiratory virus infections. PLOS One 7(5): e37334. doi:10.1371/journal.pone.0037334. PMID: 22615983 PMCID: PMC3353936. PubMed link.

Jacob Yount (2002-2007)

Position in the Lopez Lab: Graduate Student (co-mentor), Mount Sinai School of Medicine, NY.

Went to: Postdoctoral Fellow, Rockefeller University, NY

Current position: Associate Professor with tenure, Center for Microbial Interface Biology, Ohio State University.

Publications:

1. López CB, Yount JS and Moran TM. (2006) Minireview. TLR-independent Triggering of Dendritic Cell Maturation by Viruses. J. Virol. 80:3128-3134. PMID: 16505141, PMCID: PMC1440398. PubMed link.2. López CB, Yount JS, Hermesh T and Moran TM. (2006) Sendai Virus Infection Induces Efficient Adaptive Immunity Independently of Type I IFNs. J. Virol. 80:4538-4545. PMID: 16611914, PMCID: PMC1472017. PubMed link.3. Yount JS, Kraus T, Horvath C, Moran TM and López CB. (2006) A Novel Role for Defective Interfering Particles in Enhancing Dendritic Cell Maturation. J. Immunol. 177:4503-4513. PMID: 16982887. PubMed link.4. Yount JS, Moran TM and López CB. (2007) Cytokine-Independent Upregulation of MDA5 in Viral Infection. J. Virol. 81:7316-7319. PMID: 17475649, PMCID: PMC1933291. PubMed link. 5. Yount JS, Gitlin L, Moran TM and López CB. (2008) MDA5 Participates in the Detection of Paramyxovirus Infection and is Essential for the Early Activation of DCs in Response to SeV DI Particles. J. Immunol. 180:4910-4919. PMID: 18354215. PubMed link. 6. Cotter C, Kim WK, Nguyen M, Yount J, López CB, Blaho, and Moran TM. (2011) The Virion Host Shut-off (vhs) Protein of HSV-1 Blocks the Replication-Independent Activation of NF-κB in Dendritic Cells. J. Virol. Sept 21, EPub Ahead of Print. PMID: 2193765. PubMed link.

Vet students

Ali Sanz (summer 2017)

PennVet Student

Emma Price (summer 2016, winter 2018/19)

PennVet Student

Undergrads

Geyon Lee Garcia (2016-2019)

Post-Bach trainee and PREP scholar, UPenn

Went to: MD/PHD program at University of Pittsburgh

Ker-Cheng Chen (2017)

Undergraduate Student, 2017,UPenn

Position: School of Arts & Sciences, UPenn.

Christiana Shaw (2016)

Undergraduate Student, UPenn

School of Arts & Sciences, UPenn

Lauren Chun (2014-2016)

School of Arts & Sciences, UPenn

Went to: Research Assistant @ UCSF

Current position: MD student at UCSD

Publications:

1. Xu J, Mercado-López X, Grier J, Kim WK, Chun L, Irvine EB, Del Toro Y, Kell A, Hur S, Gale M, Raj A, and López CB. (2015) Identification of a Natural Viral RNA Motif that Facilitates Viral Recognition by RIG-I-Like Receptors. mBio 6(5):e01265-15. doi:10.1128/mBio.01265-15. PubMed link

Derek Standlee (2014-2016)

School of Arts & Sciences, UPenn

Went to: Vet School at Tufts.

Micah Gilbert (2013-2015)

School of Arts & Sciences, UPenn

Publications:

1. Sun Y, Jain D, Koziol-White CJ, Genoyer E, Gilbert M, Tapia K, Panettieri RA, Hodinka RL, and López CB. (2015) Immunostimulatory Defective Viral Genomes Promote Strong Innate Antiviral Responses During Respiratory Syncytial Virus Infection in Mice and Humans. PLOS Pathogens. 11(9): e1005122. doi:10.1371/journal.ppat.1005122 PubMed link

Emily Dunay (2011-2015)

School of Arts & Sciences, UPenn

Went to: Vet School University of Pennsylvania School of Veterinary Medicine.

Publications:

1. Tapia K, Kim WK, Sun Y, Mercado-López X, Dunay E, Wise M, Adu M, and López CB. (2013) Defective Viral Genomes Arising In Vivo Provide Critical Danger Signals for the Triggering of Lung Antiviral Immunity. PLOS Pathogens 9(10): e1003703. doi:10.1371/journal.ppat.1003703. * Featured Article. *Co-first authors. PubMed link

Lakshimi Bhagavathula (2012-2013)

UPenn, Master in Biotechnology

Went to: Research Specialist Penn Gene Targeting Core

Current position: Graduate Student (PhD) at Rutgers University, NJ.

Olga Herrera (2009-2010)

PREP Student, Mount Sinai School of Medicine, NY.

Went to: continued PREP program at Mount Sinai, NY.

Current position: Regeneron, NY.

Research Assistants

Alex Valenzuela (2015-2017)

Position: Research Specialists A since September, 2015

Went to: Post bach at UCSF

Current: MD student at UCLA

Publications:

1. Muallem G, Wagage S, Sun Y, DeLong JH, Valenzuela A, Harms Pritchard G, Christian, DA, Fang, Q, Buza E, Jain D, Elloso MM, López CB#, and Hunter CA#. (2017) IL-27 Limits Type 2 Immunopathology Following Parainfluenza Virus Infection. PLOS Pathogens 13(1):e1006173. doi: 10.1371/journal.ppat.1006173. #Senior authors. Publication link.2.Sengupta S, Tang S, Devine J, Anderson S, Nayak S, Zhang C, Valenzuela A, Fisher D, Grant G, López CB, and FitzGerald G. (2019) Circadian control of lung inflammation in influenza infection. Nature Communications, doi.org/10.1038/s41467-019-11400-9.

Deepika Jain, Ph.D (2011-2014)

Position: Research Specialist D / Lab Manager.

Went to: Eurofins Group, PA

Publications:

1. Hermesh T, Moran TM, Jain. D, and López CB. (2012) Granulocyte colony-stimulating factor protects mice during respiratory virus infections. PLOS One 7(5): e37334. doi:10.1371/journal.pone.0037334. PMID: 22615983 PMCID: PMC3353936. PubMed link.2. Kim WK, Jain D, Sánchez MD, Koziol-White C, Matthews K, Ge M, Haczku A, Panettieri RA, Frieman MB, and López CB. (2014) Deficiency of Melanoma Differentiation-associated protein 5 results in Exacerbated Chronic Post-Viral Lung Inflammation. Am. J. Respir. Crit. Care Med. 189(4):437-48. doi: 10.1164/rccm.201307-1338OC. PMID: 24417465. PubMed link.3. Sun Y, Jain D, Koziol-White CJ, Genoyer E, Gilbert M, Tapia K, Panettieri RA, Hodinka RL, and López CB. (2015) Immunostimulatory Defective Viral Genomes Promote Strong Innate Antiviral Responses During Respiratory Syncytial Virus Infection in Mice and Humans. PLOS Pathogens. 11(9): e1005122. doi:10.1371/journal.ppat.1005122 PubMed link

Karla Tapia (2008-2012)

Position: Research Specialist C

Went to: Research Technician, Universidad Católica de Chile.

Publications:

1.Neil RC, Tapia KA, Dandapani A, MacArthur BD, López C, Ma’ayan A. (2011). Stochastic model of virus and defective interfering particle spread across mammalian cells with immune response. Q-bio.PE, arXiv:1108.4901. Publication link.2. Mercado-López X, Cotter CR, Kim WK, Muñoz L, Sun Y, Tapia K, and López CB. (2013) Highly Immunostimulatory RNA Derived from a Sendai Virus Defective Viral Genome. Vaccine. 2013 Oct 4. pii: S0264-410X(13)01294-2. doi: 10.1016/j.vaccine.2013.09.040. [Epub ahead of print] PMID: 2409987. PubMed link.3. Tapia K, Kim WK, Sun Y, Mercado-López X, Dunay E, Wise M, Adu M, and López CB. (2013) Defective Viral Genomes Arising In Vivo Provide Critical Danger Signals for the Triggering of Lung Antiviral Immunity. PLOS Pathogens 9(10): e1003703. doi:10.1371/journal.ppat.1003703. * Featured Article. *Co-first authors. PubMed link4. Sun Y, Jain D, Koziol-White CJ, Genoyer E, Gilbert M, Tapia K, Panettieri RA, Hodinka RL, and López CB. (2015) Immunostimulatory Defective Viral Genomes Promote Strong Innate Antiviral Responses During Respiratory Syncytial Virus Infection in Mice and Humans. PLOS Pathogens. 11(9): e1005122. doi:10.1371/journal.ppat.1005122 PubMed link

Luis Muñoz (2003-2011)

Position: Research Specialist D, Lab manager

Went to: ImClone, NY

Publications:

1. Mercado-López X, Cotter CR, Kim WK, Muñoz L, Sun Y, Tapia K, and López CB. (2013) Highly Immunostimulatory RNA Derived from a Sendai Virus Defective Viral Genome. Vaccine. 2013 Oct 4. pii: S0264-410X(13)01294-2. doi: 10.1016/j.vaccine.2013.09.040. [Epub ahead of print] PMID: 2409987. PubMed link.

Rotations and Summer Students

Brian Goldspiel, MD/MPD (UPenn, MVP), Summer, 2019

Edwin Ovalle, (UPenn, SUIP), Summer, 2019

Victoria Lovins (MVP Program, Cell & Molecular Biology Graduate Group), Spring 2019

Joshua Hatterschide (MVP Program, Cell & Molecular Biology Graduate Group), Fall 2017

Katherine Strelau (MVP Program, Cell & Molecular Biology Graduate Group), Fall 2017

David Yang (UPenn, SAS), Summer, 2017

Gregorio Benitez (Brown University, UPenn, SUIP), Summer 2017

Sangya Agarwal (UPenn, CAMB-GTV), Fall 2016

Andrew Hart (UPenn ,IGG), Fall 2016

Courtney Comar (UPenn, CAMB-MVP), Spring 2016

Eddie Irvine (UPenn, SUIP), Summer 2014

Wenzhi Song (Bryn Mawr College), Summer 2014

Ethan Mack (UPenn, IGG, MD/PhD), Fall 2013

Alexis Leanza (UPenn, CTSA Internship), Summer 2013

Cristhian Cadena (UPenn, SUIP), Summer 2012 and 2013

Tori Yamamoto (UPenn, IGG), Fall 2012

Julia Rood (UPenn, IGG, MD/PhD), Fall 2012

Joshua Sherman (UPenn, Vagelos Program in Life Sciences & Management), Spring 2012

Steven Siegel (UPenn, MVP, MD/PhD), Fall 2011

Megan Wise (UPenn, MVP), Fall 2011

Jerome Molleston (UPenn, MVP, MD/PhD), Summer and more 2011

Michael Adu (UPenn, SUIP), Summer 2011

Sabrina Tsang (UPenn, MVP), Spring 2011-Fall 2012

Ciara Gimblet (UPenn, MVP), Spring 2011

Gretchen Harms (UPenn, IGG), Winter 2011

Zachary Zalinger (UPenn, MVP), Winter 2011